A hypothesis of cure for ALS MND (Amyotrophic Lateral Sclerosis Motor Neurone Disease)

And explore useful techniques for potentially related trauma healing following a collision sport game. © July 2026

By Phillip D Wade B. Pharm. ND Adv. Bot Med D. Clin Nutr D. DRM MATMS 9879

3/152 Burns Bay Rd, Lane Cove. NSW, Australia 2066 Ph: 0414805154

Purpose

To achieve a cure for ALS MND using complementary medicine combined with orthodox medicine where available.

Goals

To: apply specific treatments simultaneously to enable nerve recovery from relevant infections and toxic insults, simultaneously or successively, that affect performance of astrocytes (aka glial cells) whose under performance is the major fundamental cause of ALS MND.

Investigate all possible causes of MND including that caused by maladaption of certain immune cells.

Investigate all known and potential treatments of related conditions involving demyelination and nerve dysfunction

Combine if necessary allopathic solutions with natural therapies

Investigation Objectives

To identify:

all destructive agents of astrocytes and offspring motor neurones and apply the treatments that may eradicate them.

agents that enhance the structure and viability of astrocytes and their offspring motor neurones, and apply them.

Myelin insufficiency:

That Demyelination of nerves is the principle cause of dysfunction

That Unhealthy Astrocytes won’t produce myelin by attack from immune cell mimicry

How to enhance Immune cell activity – especially cytomegalovirus

Epstein Barr family of neurogenic viruses set up attack on nerves – in particular cytomegalovirus

Nutrient deficiency may consequently lead to poor defence against viruses and microbes

Immune system deficiencies lead to infection in key tissues

Microbial involvement: parasitic, bacterial, fungal, mould, yeast or other

Treatment objectives

To restore myelination function of astrocytes and axonal membrane of motor nerves .

To use existing treatments of similar aetiologies that may destroy infections and support re-growth of tissue

Use specifically Frequency Specific Microcurrent as a major treatment

To replenish deficient nutritional status universally including gut microbiome.

Discussion

While it is known that both glandular fever and cytomegalovirus infections are commonly occurring, as are for example candida and mould or other microbial infections, it is not known if unusual combinations of pathology occurring simultaneously may cause the pathology of the nervous system to initiate a slow decline in nerve function that is typical of MND.

The purpose of this initiative is in making that assumption, to treat both glial cells and immune calls accordingly and see what eventuates. In other words, to paraphrase the late Prof. Richard Scolyer, “have a crack”.

While herpes family viridae have been dismissed as not being potentially lethal neurotoxic agents that cause cell death in adults, the large virus in that family – cytomegalovirus – has been universally implicated in nerve intracellular damage.

Cytomegalovirus (CMV)

Once it has entered a nerve cell, not only does it divert antibodies from attacking its own surface to that of the inner viral structures that it mimics – but it also produces “false flag” molecules to draw attack from the TH1 immune system, depleting its ability to attack its own main body.

Known cell death caused by CMV alone.

And also, as mentioned, can induce cell death of the neurone in very rare cases.¹ if inflammatory conditions such as injury or allergy recur.

As for other theories of viral toxicity like “junk DNA” imposing itself on causing mis-firing DNA replication, or activating historic virion that are “buried: in the “junk”, that theory must be taken seriously until otherwise disproven, and acted upon where possible.

The gradual onset of necrosis and cell death² of neuronal material within nerve cells also cannot be discounted as possibly happening in “rare cases” much as happens in embryos, and measures taken to address that. The reason why? If MND is such a rare (and incurable) condition, then it is reasonable to hypothesise that in rare cases of infants acquiring cell death from CMV infection that it is also possible, though rare, for intracellular cell death in an adult in 1 in 100,000 cases.

In other words, because orthodox measures have failed to curb this disease, unorthodox measures of poly-treatment, poly-system approach – yet harmless to the patient – must be considered as a viable alternative.

 

 

Astrocyte damage at symptomatic levels that are needed to start symptoms.

Myelin insufficiency

• • • Demyelination of nerves causes dysfunction.
    • Initial infection by Cytomegalovirus (CMV), and other Epstein Barr viridae (EBV) causes demyelination as well as internal nerve inflammation in cranial and subsequently lateral spinal nerves and eventually the muscles and organs that they control.
    • This may cause fatigue from liver damage as a major symptom as well as other organs.
    • This in turn limits the ability to take in enough food to sustain energy.
    • Immune deficiency can occur due to virus attack on immune cells that defend the body from infection.
    • Other microbial infections, Viral infections

Epstein Barr virus of probable implication in MND-myelin insufficiency – aetiology

While officially there is no known cause of ALS MND (Short for Amyotrophic Lateral Sclerosis Motor Neurone Disease), this 2002 press release of a previously embargoed study in 1969 found that it is true that sports people – particularly elite sportspeople – have a significantly higher instance (1.7 times) of contracting this disease. In addition to people who had “been slim all their lives:”had an even higher (2.2 times) instance of contracting it.³ It is a pity that they embargoed the original study of Lou Gehrig’s disease (original name of MND) because, while I believe that it is true that Cytomegalovirus⁴ is a main player of astrocyte demyelination nerve-damage-driven MND, I also believe that this paper gives us a massive clue to confront and defeat the disease. From a second and ultimately related cause – so-called “slimness” occurrence.

Other pathologies need to coincide to introduce “rarity” of condition as well as the lethal ability.

And as infection with this virus alone cannot cause MND without the help of other things going wrong simultaneously, such as poor immune response due to its rarity of occurrence, then the proof that multiple insults to the astrocytes and not a single incident are needed is strengthened by the 1969 study.

The clue to EBV involvement in the above study along with slimness and fatigue and also including cytomegalovirus lies in this Harvard health study⁵

So what common infection can cause both physical wasting and loss of nerve function? Answer: an unfortunate coinfection of both Herpes simplex and cytomegalovirus.

Herpes simplex – or glandular fever – infects specifically the trigeminal nerves. This causes pain. Herpes also causes liver inflammation. This virus therefore not only causes “slimness” but also pain in the mouth and lips and tongue. It also causes “trigeminal neuralgia” for good measure – that in turn causes “face drop” on one side.

CMV affects fat absorption by impeding bile secretion iand inflaming the liver and gallbladde⁶ and therefore probably directly implicated in the “slimness” syndrome. CMV may also cause glandular fever type syndrome of lethargy – and exhaustion syndrome – by public or athlete⁷. FSM may have treatment for this virus, as it has for other herpes viridae.⁸

Adding low energy, nausea from undigested fats in normal diets (and alcohol also causing a similar response) to the burden, such people become lethargic from nerve damage and low calorie intake and develop slimness. But have probably never been diagnosed with this virus in many cases, given that the antibodies to⁹ EBVs take months to develop in the serum.

And as will become evident, it is quite probable that overall fat deficiency or indeed poor fat digestion/absorption may be a cause. And CMV has also been linked to gall bladder, bile duct and liver inflammation that impedes fat emulsification.

EBVs Overlooked by researchers for the wrong reasons

Why was EBV and CMV family overlooked as a cause?

Simply because “it infects the general population and MND is so rare.¹⁰

This is erroneous thinking because other viral infections act in grades of severity. e.g. poliovirus infects 80-95% of people in epidemics but relatively few develop the disastrous symptoms.¹¹

EBVs in turn will definitely affect poor absorption of all the fat soluble vitamins – Vitamin A¹², E¹³, K¹⁴ as well as vitamin D¹⁵.All fat soluble vitamin deficiencies cause general nerve dysfunction with the exception of vitamin A that applies specifically to optical (eye) nerves.

 

Fat deficiency

That means that fat absorption impairment is a contributing factor. And yet this leads to another question – does impact-induced hypoxia have an affect on normal nerve function?

Tissue Hypoxia impairs tissue recovery including nerves.

Impact induced hypoxia (oxygen starvation to tissue): There is evidence from this study that collision sports may lead to hypoxia if not properly managed.¹⁶

And that bruising induced hypoxia in turn will impair recovery.¹⁷

And FSM treatment along with arnica ingestion ¹⁸may remove bruising.¹⁹

And it is feasible that the accumulation of head injuries that are suspected to be part of CTE issues may lead to semi-permanent bruising in the brain²⁰ that would be a contributor to poor circulation, hypoxia and ALS MND.²¹

So, all we need to do is to find treatments of the above, individually and collectively and we’re home and hosed”. And I believe that this is possible.

We also know that a virus called cytomegalovirus has been directly implicated by this 2023 study.²²

Hypothesis of cure of MND.

Given that attempts to cure MND have involved monotherapy that addresses only one of the causative issues at any one time, then MND may well respond to treating it with a variety of potentially relevant and complementary methods that address several causative factors and symptoms simultaneously, or at least sequentially including the above identified causative factors and others below highlighted in “discussion”.(see table below).

Discussion

Major proposed treatment *Frequency Specific microcurrent.

²³(FSM) is a powerful yet harmless technology due its ability to specifically target both tissue and pathology may provide the breakthrough technology that enables recovery from MND involving Amyotrophic Lateral Sclerosis – and perhaps other forms.

*FSM provides a suite of frequencies that have been shown to increase cellular output of ATP (by 500%), protein production by 70%, endorphins by 5,000%. FSM is my anchor and “go-to” choice of therapy. It has impressive science and is now, finally, approved by the FDA.

In addition to that it provides a long list of frequencies that have anti-pathology actions that have been little used for many decades due to restrictions imposed by FDA and TGA regulations.

It has been used successfully to so treat such viral/neurological issues as MS.

This study of MS (Multiple Sclerosis) – although a non-identical condition. Is one conducted under strict, reproducible conditions however, and is an indicator that – with a suitable adjustment for the special features of ALS MND – improvement in the condition using FSM principles at least may be possible.

A full list of such underlying causes and selected treatments is shown in a table below.

And all traditionally helpful and harmless herbs or nutrients or treatments will be included as the risk-benefit ratio for treatment of MND of practically every traditional botanical herb or targeted nutritional could not possibly be more harmful that the short term and lethal prognosis of ALS MND itself – even with the most modern RNA-DNA-genic treatments.

Comment

Given that no “known” cause of or cure for MND has yet come to light, but will occur in cases of *immunodeficiency, then logic dictates that cytomegalovirus (CMV) itself is the potentially major cause²⁴, given all available literature as to cause. CMV is the major suspect due to the following reasons, and therefore every effort must be made to:

* Immunodeficiency may occur in players exposed to constant injury, when steroids have been administered²⁵ in the healing process for reasons of injury inflammation or e.g. to other sufferers of semi-permanent inflammation such as frequent users of steroid medication or such as asthmatics or rhinitis sufferers or body builders.

This possibility may be avoided largely by taking simple precautions. This maintains player efficiency rating and minimises future health concerns post playing years.

To counter this possibility:

1) decisevely eliminate ²⁶CMV as a major contributor in as many ways as traditional and orthodox medicine allow including with the use of FSM²⁷. And FSM is to be deemed to be harmless for the purposes of this treatment.

2) And wherever at all possible, these be given simultaneously and safely, as monotherapy – including anti ²⁸SOD1 – has proven unsatisfactory.

3) At the same time to regenerate activity of the motor nerves involved particularly in the early stages – both nerve body and myelin (mostly produced in the microglia).

4) Use FSM and arnica routinely so as to minimise the need for anti-inflammatory steroids.

5) Until otherwise proven, introduce such measures that are harmless and can only deliver zero or active binary choice – rarely if ever a negative outcome.

6) Other anti-viral and equally harmless measures can be taken simultaneously – even traditionally harmless “experimental” ones if not yet sufficiently “trialled”, including traditional herbs and harmless, targeted nutrition.

7) Other harmless measures such as sinus rinses, adequate hydration, assisting with circulation for inactive patients and so on.

8) So-called ‘Leaky gut’ (intestinal permeability) may create a chronic health challenge²⁹, is avoidable can be reversed using probiotics.

Some Boring Details for pathophysiology nerds like me

Its mode of action as a herpes virus is to attack the astrocyte (glial) neuronal cells³⁰ that subsequently die that are at the genesis of ALS, despite the need of other neurotoxic factors to be present simultaneously.

As this is the same type of MND that is affecting Jai Arrow and that affected former AFL great and MND sufferer, the late Neale Daniher before him – as well as many other sufferers of MND. And that – aided by other factors – may lead to the susceptibility of dysfunction of the micro-glial or Astrocyte brain cells. And given that CMV is a virus of the herpes family – other members of which cause other nerve infections such as shingles, chicken pox and trigeminal neuralgia – then by reducing the level of this virus contamination we may reduce its lethal affect on the microglia.

Further, that by combining multi-therapy treatments of pharmaceutical, medical and natural therapies, barring treatment incompatibilities and also searching and treating for the totality of potential causes, then a different outcome may be achieved, whereas singling out individual causes and treating with or investigating outcomes with mono therapies have failed to date.

Known or suspected direct or indirect complications/contributors of ALS MND

1) Cytomegalovirus

2) ³¹“junk” DNA and dormant “ancient” viridae.

3) Known oncogene and tumour suppressor gene stabilisers

5) Immunosuppression and steroid use

6) Virus-propagating dietary elements to avoid e,g, arginine foods

7) Microbial infections and parasites³²

7a) Dietary inhibitors³³ of viral reproduction e.g. tyrosine foods and “activation” of grains

7b) ³⁴All raw foods to be soaked before consumption and of pesticide-free origin (organic) – and other methods of preparation.

8) Poor fat absorption from gall bladder or common bile duct issues or

9) ³⁵low dietary fat intake

7C ³⁶Microbial infections…Antibacterial elements that are active inside neurones including astrocytes and microglial cells

Suggested treatments

1. Anti-parasite medicines

2. Known antioxidants

 

3. Herbal and ³⁷ pharmaceutical inhibitors of herpes virus – especially CMV.

9) Myelin building nutrients³⁸

10) Neurone supporting herbs, nutrients and meds

11) Herbal stimulants of immune activity³⁹

12) Vitamin stimulants of neuro-structural⁴⁰ and immune activity⁴¹ – ensure all known micronutrients included in diet. To acceptable levels of intake as recommended by the ABS⁴²

13) Nerve-specific anti-inflammatories – herbal⁴³, nutritionaland/or pharmaceutical⁴⁴

14) Nutritional elements that support nerve sheath such as lecithin⁴⁵

15) Nutritional elements supporting nerve axonal or dendritic membrane growth

16) Known nutritionals that support neuronal ATP production

17) Frequency Specific Microcurrent (FSM) to frequencies that may support pain and inflammation, ATP and Endorphin production, reduce cellular cytokines, reduce tissue necrosis, repair tissue and inhibit virus activity and emerging pathology where identified.

18) OSA – CPAP therapy

Differential diagnosis	Suggested Treatments
CMV	Sod Ascorbate, lysine; FSM; anti-viral med; dietary deletions e.g. arginine; dietary inclusions eg tyrosine; delete pesticides in foods or local environment; have organic foods; soak oxalates and phytates; Wades Smoothi +Phil’s Oils for cell nutrient, antioxidant and probiotic support
Junk DNA “ancient virus”	Wades Smoothi +Phil’s Oils for cell nutrient, antioxidant and probiotic support above
DNA attack by other herpes viridae	Curcuminoids; Hydrolysed citrus pectin; Wades Smoothi +Phil’s Oils for cell nutrient, antioxidant and probiotic support
Pesticides	Avoidance – use organic foods only; Wades Smoothi +Phil’s Oils for cell nutrient, antioxidant and probiotic support
Peroxidated lipids – such as ingesting heated unsaturated oils	Additional Antioxidants, lecithin, vitamins A,D,E,K. AS FOR CMV; Wades Smoothi +Phil’s Oils for cell nutrient, antioxidant and probiotic support
Exposure to solvents (e.g. paint, glue, petroleum products)	Avoidance, lecithin, A,D,E,K, AS FOR CMV; plus Wades Smoothi +Phil’s Oils for cell nutrient, antioxidant and probiotic support
Immune compromise	Above; ginseng; Essiac; Phil’s composite smoothi, AS FOR CMV including Wades Smoothi +Phil’s Oils for cell nutrient, antioxidant and probiotic support; FSM
Intra neurone bacterial infections; gut dysbiosis;	Probiotics – acidophilus, bifidus, rhamnosis, paracacea, plantarum; FSM
Parasites	Mebendazole, vlack walnut; Artemisia annua, absinthium.probiotics; whey, colostrum; FSM
Brain neurone decline	Bacopa, ginkgo, lecithin, above; FSM
Undernutrition	Phil’s Smoothi, Phil’s Oils;
Atp support	Ubiquinol + FSM
Brain hypoxia	CPAP; Treat cause and effects (e.g. sinusitis? Eating earlier? Diaphragm hernia? Other?
All above causes	FSM
Sinus infection	Saline wash; probiotics; gaviscon or similar; Losec;
Refluix-→simusitus → infection also → breathing barrier while sleeping-→pressure on diaphragm → sleep apnoea	Surgery on abdominal diaphragm plus above
Obstructive Sleep Apnoea	CPAP plus above see local Pharmacy CPAP specialist

* Given the lack of medical treatment available, for MND etc it will be agreed that if suggested treatments/meds are harmless and beneficial, then they shall be approved, pending the consent of the patient. It will be agreed that the various meds and nutrients will be compatible and compounded in as few units as possible in as least invasive manner as possible that is tolerable to taste.

Any medical anti-inflammatory drugs will be non-steroidal in nature of necessity so as to maximise immune potential, given the immune-compromising effect of that category.

Phil Wade 20/6/2026

* Given the lack of medical treatment available, it will be agreed that if suggested treatments/meds are harmless and beneficial, then they shall be approved, pending the consent of the patient. It will be agreed that the various meds and nutrients will be compatible and compounded in as few units as possible in as least invasive manner as possible that is tolerable to taste.

Any medical anti-inflammatory drugs will be non-steroidal in nature of necessity so as to maximise immune potential, given the immune-compromising effect of that category.

Phil Wade 20/6/2026