Overarching principle of searching for a cure:  Think outside the box and ditch all preconceived bias born in ignorance, given that any attempt at monotherapy – genetic or otherwise – has no remote likelihood of working in the short term.

By Phillip D Wade B. Pharm. ND Adv. Bot Med D. Clin Nutr D. DRM MATMS 9879

3/152 Burns Bay Rd, Lane Cove. NSW, Australia 2066 Ph: 0414805154 20/06/2026

Purpose

The purpose of this paper is – as the name implies – to collate all the known causes and complications of motor neurone disease or MND – both direct and indirect – as well as treatments, for the purpose of ultimately reversing the disease.

Then to proceed to recovery, using the property of astrocyte-driven neuroplasticity that was first described by Prof Michael Merzenich then of the University of California. And to find a method to address that by using synergistic properties of compatible, combination therapies. Especially as this method has already proven harmless and successful in other instances of chronic illness. 

And, given the current lack of known treatments and of success in dealing with MND in simply using an allopathic (medical) systematic route, perhaps using a different approach might provide a different answer.

And it has now been proven beyond doubt that breakdown motor neurones are the actual cause of MND and nor merely muscular dystrophy.

And with my naturopath hat on, and given that I am also a (recently retired) pharmacist, I would certainly find it more than useful to “have a crack” and combine the two methods/treatments of investigating and treating known causes of a condition – rather than merely treating symptoms or investigating/applying single agents/approaches one at a time. And therefore in combining any available medical treatment with a naturopathic approach.

Goal

To use a wholistic approach that would in this case investigate all known causes of nerve challenges, look at common aetiologies involved, find herbs, targeted nutrition and combine them with medical treatments and quite easily fit them into a matrix of treatments that would easily combine with practically any “trial drug” like a hand in a glove. And any potential interactions can be easily identified and catered for.

The justification for this “connect the the individual silos of knowledge into a concerted attack” approach is that the current, more allopathic approach has failed, the suggested treatments herein are harmless and – to paraphrase the late Prof Richard Scolyer – in that case, why not “give it a crack”.

Introduction

It is a fact that many potential agents/conditions may cause nerve debility (see below).

However, while herpes family viridae have been dismissed as neurotoxic agents that cause cell death in adults, the largest member of that family – cytomegalovirus – along with others has been implicated in affecting normal responses from immune cells called T cells in behaving differently from the other cells of that family, in being able to divert antibodies from attacking the viral surface to that of the inner neuronal structures that it mimics. In this study, CMV was found to produce “false flag” proteins to potentially destroy brain cell structures in drawing attack from the TH1 immune system away from the virus itself, and instead attacking the real structures that it mimicked. This in turn has led to the destruction of the cell itself in certain rare cases.

So if we can find a method to target the CMV instead then we might just take a huge step in neutralising the major causative agent – CMV.

Evidence for potential of Cytomegalovirus as a major causative agent and potentially successful treatment – FSM.

While a hypothesis cannot be proven or disproven – by definition – it is important that each research step of evidence leading to the conclusion – quid est datum –  be proven. So in that light, I offer the following as such steps. And while it has been “dismissed” – along other family members of Herpes viridae as a causative agent simply because “95% of people are infected with Herpes simplex or other – then it is up to this paper to disprove that (very lazy) eliminative cause leading to a false conclusion.

And if we can reinstate this virus as a major threat, all we have to do is eliminate the virus itself. And  DNA research – along with natural therapy – targeting of this virus will definitely be a winner in the quest to halt and even recover somewhat – from MND and similar neurological conditions like PMA. As will FSM.

So, the text below re the implication of CMV quotes directly a report from the National Institute of Health to avoid an unintended misquoting in the attempted summary above.

NIH description of the mode of action of cytomegalovirus…

Assessing and treating Amyotrophic Lateral Sclerosis Motor Neurone Disease (MND) for all contributing causes. ©

What causes ALS MND

Poor absorption of nerve nutrients.

While officially there is no known cause of ALS MND (Short for Amylotrophic Lateral Sclerosis Motor Neurone Disease), this 2002 press release of a previously embargoed study of a ‘69 study found that it is true that sports people – particularly elite sportspeople – have a significantly higher instance (1.7 times) of contracting this disease. In addition people who had “been slim all their lives: had an even higher (2.2 times) instance of contracting it.¹ It is a pity that they embargoed the original study because, while I believe that it is true that Cytomegalovirus² is a main player of astrocyte nerve-damage-driven MND, I also believe that this paper gives us a massive clue to confront and defeat the disease.

And as infection with this virus alone cannot cause MND without the help of other things going wrong simultaneously, due to its rarity of occurrence then the case of prroof of cause and possible treatments of cure are possible.

CMV affects fat absorption by impeding bile secretion in inflaming the liver and gallbladde³ and therefore probably directly implicated in the “slimness” syndrome. CMV may also cause glandular fever type syndrome of lethargy – and exhaustion syndrome – by public or athlete⁴. FSM may have treatment for this virus, as it has for other herpes viridae.⁵

This family of viruses typically affects fat absorption by inflaming the bile duct and liver, that is responsible for fat emulsification that is necessary for absorption into the liver where it is digested.

And as will become evident, it is quite probable that overall fat deficiency or indeed poor fat digestion/absorption may be a cause. And CMV has been linked to gall bladder, bile duct and liver inflammation that impedes fat emulsification.

This in turn will definitely affect poor absorption of all the fat soluble vitamins – Vitamin A⁶, E⁷, K⁸ as well as vitamin D⁹.All fat soluble vitamins cause general nerve dysfunction with the exception of vitamin A that applies specifically to optical (eye) nerves.

So the fat absorption impairment is a contributing factor. And yet this leads to another question – does impact-induced hypoxia have an affect on normal nerve function?

Impact induced hypoxia (oxygen starvation to tissue): There is evidence from this study that collision sports may lead to hypoxia if not properly managed.¹⁰

And it is feasible that the accumulation of head injuries that are suspected to be part of CTE issues may lead to semi-permanent bruising in the brain¹¹ that would be a contributor to ALS MND.¹²

So, all we need to do is to find treatments of the above, individually and collectively and we’re home and hosed”. And I believe that this is possible.

We also know that a virus called cytomegalovirus has been directly implicated by this 2023 study.¹³

Hypothesis of cure of MND.

Given that attempts to cure MND have involved monotherapy that addresses only one of the causative issues at any one time, then MND may well respond to treating it with a variety of potentially relevant and complementary methods that address several causative factors and symptoms simultaneously, or at least sequentially including ther above identified causative factors and others below highlighted in “discussion”.(see table below).

Discussion

Major proposed treatment *Frequency Specific microcurrent.

¹⁴(FSM) is a powerful yet harmless technology due its ability to specifically target both tissue and pathology may provide the breakthrough technology that enables recovery from MND involving Amyotrophic Lateral Sclerosis – and perhaps other forms.

*FSM provides a suite of frequencies that have been shown to increase cellular output of ATP (by 500%), protein production by 70%, endorphins by 5,000%. FSM is my anchor and “go-to” choice of therapy. It has impressive science and is now, finally, approved by the FDA.

In addition to that it provides a long list of frequencies that have anti-pathology actions that have been little used for many decades due to restrictions imposed by FDA and TGA regulations.

It has been used successfully to so treat such viral/neurological issues as MS.

This study of MS (Multiple Sclerosis) – although a non-identical condition. Is one conducted under strict, reproducible conditions however, and is an indicator that – with a suitable adjustment for the special features of ALS MND – improvement in the condition using FSM principles at least may be possible.

A full list of such underlying causes and selected treatments is shown in a table below.

And all traditionally helpful and harmless herbs or nutrients or treatments will be included as the risk-benefit ratio for treatment of MND of practically every traditional botanical herb or targeted nutritional could not possibly be more harmful that the short term and lethal prognosis of ALS MND itself – even with the most modern RNA-DNA-genic treatments.

Comment

Given that no “known” cause of or cure for MND has yet come to light, but will occur in cases of *immunodeficiency, then logic dictates that cytomegalovirus (CMV) itself is the potentially major cause¹⁵, given all available literature as to cause. CMV is the major suspect due to the following reasons, and therefore every effort must be made to:

* Immunodeficiency may occur in players exposed to constant injury, when steroids have been administered¹⁶ in the healing process for reasons of injury inflammation or e.g. to other sufferers of semi-permanent inflammation such as frequent users of steroid medication or such as asthmatics or rhinitis sufferers or body builders.

1) decisevely eliminate ¹⁷CMV as a major contributor in as many ways as traditional and orthodox medicine allow including with the use of FSM¹⁸. And FSM is to be deemed to be harmless for the purposes of this treatment.

2) And wherever at all possible, these be given simultaneously and safely, as monotherapy – including anti ¹⁹SOD1 – has proven unsatisfactory.

3) At the same time to regenerate activity of the motor nerves involved particularly in the early stages – both nerve body and myelin (mostly produced in the microglia).

3) Until otherwise proven, introduce such measures that are harmless and can only deliver zero or active binary choice – rarely if ever a negative outcome.

4) In the spirit of cure then other anti-viral and equally harmless measures can be taken simultaneously – even traditionally harmless “experimental” ones if not yet sufficiently “trialled”, including traditional herbs and harmless, targeted nutrition.

5) Other harmless measures such as sinus rinses, adequate hydration, assisting with circulation for inactive patients and so on.

Some Boring Details for pathophysiology nerds like me

Its mode of action as a herpes virus is to attack the astrocyte (glial) neuronal cells²⁰ that subsequently die that are at the genesis of ALS, despite the need of other neurotoxic factors to be present simultaneously.

As this is the same type of MND that is affecting Jai Arrow and that affected former AFL great and MND sufferer, the late Neale Daniher before him – as well as many other sufferers of MND. And that – aided by other factors – may lead to the susceptibility of dysfunction of the micro-glial or Astrocyte brain cells. And given that CMV is a virus of the herpes family – other members of which cause other nerve infections such as shingles, chicken pox and trigeminal neuralgia – then by reducing the level of this virus contamination we may reduce its lethal affect on the microglia.

Further, that by combining multi-therapy treatments of pharmaceutical, medical and natural therapies, barring treatment incompatibilities and also searching and treating for the totality of potential causes, then a different outcome may be achieved, whereas singling out individual causes and treating with or investigating outcomes with mono therapies have failed to date.

Foreword *

The purpose of this paper is – as the name implies – to collate all the known causes and complications of MND – both direct and indirect – as well as treatments of that genre for the purpose of attempting to stabilise the disease progression as the first step towards some as yet unknown attempt to reverse the disease – which can only be done using/supporting the known process of neuroplasticity and preventing attack by CMV.

And to attempt to tie them together in the form of combined treatment to that end.

Introduction

While herpes family viridae have been dismissed as neurotoxic agents that cause cell death in adults, the large virus – cytomegalovirus – has been universally implicated in not only diverting antibodies from attacking its own surface to that of the inner viral structures that it mimics but it also emits “false flags” to draw attack from the TH1 immune system, depleting its attack by exhausting its activity.

And also, as mentioned, can induce cell death of the neurone in very rare cases.²¹ if inflammatory conditions such as injury or allergy recur.

As for other theories of viral toxicity like “junk DNA” imposing itself on causing mis-firing DNA replication, or activating historic virion that are “buried: in the “junk”, that theory must be taken seriously until otherwise disproven, and acted upon where possible.

The gradual onset of necrosis and cell death²² of neuronal material within nerve cells also cannot be discounted as possibly happening in “rare cases” much as happens in embryos, and measures taken to address that. The reason? If MND is such a rare (and incurable) condition, then it is reasonable to hypothesise that in rare caese of infants acquiring cell death from CMV infection that it is also possible, though rare, for intracellular cell death in an adult in 1 in 100,000 cases.

In other words, because orthodox measures have failed to curb this disease, unorthodox measures of poly-treatment, poly-system approach – yet harmless to the patient – must be considered as a viable alternative.

Known or suspected direct or indirect complications/contributors of ALS MND

1) Cytomegalovirus

2) ²³“junk” DNA and dormant “ancient” viridae.

3) Known oncogene and tumour suppressor gene stabilisers

5) Immunosuppression and steroid use

6) Virus-propagating dietary elements to avoid e,g, arginine foods

7) Microbial infections and parasites²⁴

7a) Dietary inhibitors²⁵ of viral reproduction e.g. tyrosine foods and “activation” of grains

7b) ²⁶All raw foods to be soaked before consumption and of pesticide-free origin (organic) – and other methods of preparation.

8) Poor fat absorption from gall bladder or common bile duct issues or

9) ²⁷low dietary fat intake

7C ²⁸Microbial infections…Antibacterial elements that are active inside neurones including astrocytes and microglial cells

Suggested treatments

1. Anti-parasite medicines

2. Known antioxidants

3. Herbal and ²⁹ pharmaceutical inhibitors of herpes virus – especially CMV.

9) Myelin building nutrients³⁰

10) Neurone supporting herbs, nutrients and meds

11) Herbal stimulants of immune activity³¹

12) Vitamin stimulants of neuro-structural³² and immune activity³³ – ensure all known micronutrients included in diet. To acceptable levels of intake as recommended by the ABS³⁴

13) Nerve-specific anti-inflammatories – herbal³⁵, nutritionaland/or pharmaceutical³⁶

14) Nutritional elements that support nerve sheath such as lecithin³⁷

15) Nutritional elements supporting nerve axonal or dendritic membrane growth

16) Known nutritionals that support neuronal ATP production

17) Frequency Specific Microcurrent (FSM) to frequencies that may support pain and inflammation, ATP and Endorphin production, reduce cellular cytokines, reduce tissue necrosis, repair tissue and inhibit virus activity and emerging pathology where identified.

18) OSA – CPAP therapy

* Given the lack of medical treatment available, it will be agreed that if suggested treatments/meds are harmless and beneficial, then they shall be approved, pending the consent of the patient. It will be agreed that the various meds and nutrients will be compatible and compounded in as few units as possible in as least invasive manner as possible that is tolerable to taste.

Any medical anti-inflammatory drugs will be non-steroidal in nature of necessity so as to maximise immune potential, given the immune-compromising effect of that category.

Phil Wade 20/6/2026